The evidence in favor of dopaminergic alkaloids from members of the family Lauraceae is strong and it seems likely that dopaminergic agents of clinical value might be characterized from this family, and to the Magnoliales-Laurales group in general, where isoquinoline abounds. Examples of such alkaloids are boldine and glaucine, which displace specific striatal [3H]-SCH 23390 binding in vitro. In vivo, glaucine at a dose of
40 mg/kg (intraperitoneal) abrogates climbing, sniffing, and grooming elicited by apo-morphine in mice (107). In addition, halogenation of boldine in carbon 3 leads to increased affinity for rat brain D1-ldopaminergic receptors with some selectivity over D2 receptors, suggesting that a 2-hydroxy group on the aporphine skeleton may determine a binding mode favoring D1-like over D2-like receptors (108). An additional example of a dopamine receptor-blocking alkaloid is reticuline, which is found in Ocotea species.
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