Medicinal Lamiaceae

There is an expanding body of evidence to suggest that diterpene quinone of Salvia species might represent a pool of potential inhibitors of topoisomerase. Diterpenoid quinones have been characterized from Salvia officinalis (sage, British Pharmaceutical Codex, 1934), Salvia texana, Salvia regal, Salvia moorciuftiana, and Salvia lanata (44-47).



Royleanone, horminone, and acetyl horminone isolated from the roots of Salvia officinalis L. abrogated the survival of colon carcinoma cell Caco-2 and human hepatoma cell HepG2, cultured in vitro with induction of DNA breaks (48).

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