Medicinal Convolvulaceae

An interesting feature of the Convolvulaceae is their ability to elaborate LSD-like indole alkaloids. Both Rivea corymbosa (L.) Hall and Ipomoea violacea L., from which the Mexican magical drugs ololiuqui and bado negro, respectively, are prepared, contain a number of indoles related to the ergot alkaloids. D-Lysergic acid amide (ergine) is the major constituent of the seeds of both Rivea corymbosa and Ipomoea violacea. The seeds contain also small amounts of isowergine, chanoclavine, and elymoclavine.

H3C H

H3C-N

Chanoclavine Elymoclavine

Drowsiness, apathy, and mental detachment seem to be the major effects of ololiuqui. The derivatives of lysergic acid present in ololiuqui are widely distributed throughout

the genus Ipomoea and other Convolvulaceae species. About 50 plant species from this family are used for medicinal purpose in Asia and the Pacific.

Ergine Serotonin

Lysergic acid diethylamide

/ \ /—NH HN -/
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