Coronaridine

The active constituent involved here is currently unknown, but the plant is known to produce indole alkaloids including voacangine and coronaridine, which exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, orally (14,15). Because Ervatamia pandacaqui (Poir.) Pichon elaborates iboga alkaloids, such as ibogamine and tabernanthine, and congeners, such as coronaridine, could it be a source of serotonin re-uptake inhibitors (16)?

Ervatamia corymbosa (Roxb.) King & Gamble (Tabernaemontana corymbosa Roxb. ex Wall, Pagiantha peninsularis Kerr, Pagiantha peninsularis var. brevituba Kerr, Ervatamia chinensis [Merrill] Tsiang, Tabernaemontana chinensis Merrill, Tabernaemontana yunnanensis [Tsiang] P. T. Li), or san fanggou ya hua (Chinese) or pelir kambing (Malay), is a shrub that grows to a height of 3 m tall in China, Indonesia, Laos, Malaysia, Burma, Thailand, and Vietnam. The leaves are decussate, papery, and acuminate at apex. The flowers are white, with five obliquely elliptic, mostly falcate lobes. The fruits are pairs of follicles obliquely ellipsoid (Fig. 39).

In China, the bark and leaves are used for the treatment of fractures. The roots are used in Malaysia to recover from childbirth and exhaustion, and a paste of the plant is used to treat orchitis. The plant contains indole alkaloids such as conodurinine, 19' (S) hydroxyconoduramin, 19'(S)-hydroxyervahanine A, and related iboga alkaloid congeners, and like the species mentioned earlier, and in fact the genera Ervatamia, in general, would be worth investigating for serotoninergic activities (17).

Fig. 39. Ervatamia corymbosa (Roxb.) King & Gamble. Flora of Malaya. Field No 104429. Geographical localization: Krau Game Reserve, G. Benom, Central Pahang in primary forest hillside, altitude: 1000 feet. Field collector: S. Chelliah, 7/14/1967. Botanical identification: A.J.M Leeuwenberg, 1986. Herbarium Vadense.

Fig. 39. Ervatamia corymbosa (Roxb.) King & Gamble. Flora of Malaya. Field No 104429. Geographical localization: Krau Game Reserve, G. Benom, Central Pahang in primary forest hillside, altitude: 1000 feet. Field collector: S. Chelliah, 7/14/1967. Botanical identification: A.J.M Leeuwenberg, 1986. Herbarium Vadense.

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