Cirsilineol

The central nervous properties of the plant have not yet been assessed experimentally. One might set the hypothesis that flavonoids could be involved through interference with the GABAergic nervous system as noticed previously. Some evidence has already been presented that suggests that the Artemisia species has an affinity to the GABAA receptor. Such flavonoids could be hispidulin and cirsilineol isolated from an ethyl acetate extract of Artemisia herba-alba, which displaces [3H]-flumazenil radioligand assay, have affinity to the GABAA receptor. Such flavonoids could be hispidulin and cirsilineol isolated from an ethyl acetate extract of Artemisia herba-alba which displace [3H]-flumazenil from GABA(A)-benzodiazepine receptor with IC50 values of 8 (iM and 100 ^M, respectively (57,58).

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