Subversion of Innate Immunity by Periodontopathy Bacteria via Exploitation of Complement Receptor3

George Hajishengallis1, Min Wang1, Shuang Liang1, Muhamad-Ali K. Shakhatreh1, Deanna James1, So-ichiro Nishiyama2, Fuminobu Yoshimura2, and Donald R. Demuth1 1Department of Periodontics Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA 2Department of Microbiology, Aichi-Gakuin University School of Dentistry, Nagoya464-8650, Japan Abstract. The capacity of certain pathogens to exploit innate immune receptors enables them to undermine immune...

Ficolins and Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with of unknown cause, but immune dysfunction is clearly one of its central features. H-ficolin was firstly identified as a serum antigen target for an autoantibody present in the sera of some patients with SLE. That might participate in the pathogenesis of SLE. Anti-H-ficolin antibody appears during the active hypocomplementemic phase in some SLE patients and its concentration was found to correlate positively with...

Role of Complement in Ethanol Induced Liver Injury

McMullen1, M. Edward Medof4, Abram Stavitsky3, and Laura E. Nagy1'2 1Department of Pathobiology, Cleveland Clinic, Cleveland, OH, USA, laura.nagy case.edu 2Department of Gastroenterology, Cleveland Clinic, Cleveland, OH, USA, laura.nagy case.edu 3Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA 4Department of Pathology, Case Western Reserve University, Cleveland, OH, USA Abstract. The complement cascade is a...

The Role of C5L2 Adipose vs Immune

The recent identification of C5L2 (aka GPR77) as a potential ligand for both C5a, a powerful inflammatory factor, and ASP (C3adesArg), a stimulator of triglyceride synthesis in adipocytes, has added one addition link to the interaction between the adipose and the immune system. Although there are only a limited number of papers published since the first identification of C5L2 as a potential G-protein coupled receptor in 2000 (a total of 30, six of which are review articles), controversy remains...

Ficolins and IgA Nephropathy IgAN

IgA nephropathy IgAN is a common renal disease that is characterized primarily by mesangial deposition of IgA Floege and Feehally 2000 Donadio and Grande 2002 . Earlier studies showed that IgA activates the alternative pathway of complement, whereas more recent data also indicate activation of the lectin pathway. Activation of the lectin pathway of complement is associated with more severe renal damage Roos et al. 2006 . It was also demonstrated that both MBL and ficolin were found to...

Adipose Tissue Micro Environment

Within the adipose tissue milieu, there are several ongoing processes Fig. 1 i adipocytes release factors that cause chemotaxis and infiltration of circulating macrophages ii macrophages then influence neighbouring adipocyte function iii adipocytes, in turn, simultaneously influence macrophage function iv both macrophages and adipocytes secrete factors that influence other tissues and systems, which in turn impact on the adipose tissue milieu i.e. CNS control of satiety via leptin and finally v...